Neurological Manifestations in Behcet Disease

Behçet disease is a multisystem disease of unknown cause in which an inflammatory perivasculitis can arise in almost any tissue (Sakane et al., 1999). Neurologic involvement in Behçet disease was first reported by Knapp in 1941. It represented between 4-49% of manifestations of BD (Haghighi et al., 2005). There is one of the most serious causes of long term morbidity and mortality in Behçet’s Disease. As well as, involvement of the central nervous system occurs late in the course of the disease (10–25%) (Ildan et al., 1996; Nakasu et al., 2001). It is caused by primary neural parenchymal lesions or is secondary to major vascular involvement (Adnan et al, 2009). Treatment of the most cases of NB should be given as infusion of intravenous methyl prednisolone followed by a slowly tapering course of oral steroids. (Adnan et al., 2000,). Immunopressives agents should be used in its severity forms of NB such as meningoencephalitis, deep veins thrombosis and myelopathy. In this Review, we summarise and describe the clinicals manifestations of neurobehcet disease.